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Institutional Review Boards at 11 recruiting centers approved the study protocol. The trial ended in 2010, after a median follow-up of 4.8 years, because of the observed benefit of the MedDiet compared to the low-fat control diet in the prevention of CVD. Inclusion criteria into this study are depicted in the flow diagram figure provided below, along with the CONSORT checklist for randomized trials. The control group was excluded from the present analyses because the focus of this study was the adherence with the intervention promoting the MedDiet. After providing written informed consent, participants were randomized to one of three interventions a traditional MedDiet supplemented with either complementary extra-virgin olive oil (EVOO) or tree nuts or a control diet (advice to reduce all types of dietary fat). High risk was defined as having type 2 diabetes or at least three of the following major (CVD) risk factors: current smoking, hypertension, elevated low-density lipoprotein cholesterol levels, BMI ≥25 kg/m 2, or a family history of premature coronary heart disease (CHD). Eligible participants were aged 55 to 80 and at high risk for developing cardiovascular disease (CVD). It was designed to assess the effects of the MedDiet on cardiovascular disease in 7,447 participants recruited between 20. Briefly, the PREDIMED trial was a multicenter, randomized, controlled, single-blinded cardiovascular disease prevention trial conducted in Spain. Study population Details on the PREDIMED design and methods are described in detail elsewhere. No adverse events or side effects were reported. Participants from PREDIMED recruiting centers with a higher total workload (measured as total number of persons-years of follow-up) achieved better adherence. Results Participants were randomized to the MedDiet supplemented with EVOO ( n = 2,543 1,962 after exclusions) or tree nuts ( n = 2,454 2,236 after exclusions).Ī higher number of cardiovascular risk factors, larger waist circumference, lower physical activity levels, lower total energy intake, poorer baseline adherence to the 14-point adherence score, and allocation to MedDiet + EVOO each independently predicted poorer adherence. Logistic regression was used to examine associations between baseline characteristics and adherence at one and four years of follow-up. Adherence was measured with a validated 14-point Mediterranean-type diet adherence score. Investigators assessed covariates at baseline and dietary information was updated yearly throughout follow-up. Descargar Fisiopatologia De Garcia Conde Ray Charles Ultimate Hits Collection Torrent Download there.It was the first World Cup to be held in, and the 11th time that it had been held in Europe.At an estimated cost of over 14.2 billion, it was the most expensive World Cup.The finals involved 32 teams, of which 31 came through, while. PREDIMED began in 2003 and ended in 2010. The control group and participants with insufficient information on adherence were excluded. Participants were randomized to the MedDiet supplemented with either complementary extra-virgin olive oil (EVOO) or tree nuts. Methods Analyses included men and women living in Spain aged 55–80 at high risk for cardiovascular disease.

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